Proceedings of the Korean Environmental Sciences Society Conference (한국환경과학회:학술대회논문집)
- 2008.11a
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- Pages.538-544
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- 2008
The Ligand Occupancy of Endothelial Protein C Receptor Switches the Signaling Specificity of Thrombin from a Disruptive to a Protective Response in Endothelial Cells
- Bae, Jong-Sup (Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-Industry, Daegu Haany University) ;
- Kim, Yong-Ung (Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-Industry, Daegu Haany University) ;
- Park, Moon-Ki (Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-Industry, Daegu Haany University)
- Published : 2008.11.20
Abstract
Activated protein C (APC) is thought to exert antiinflammatory activities through the endothelial protein C receptor (EPCR)-dependent cleavage of protease activated receptor 1 (PAR-1) in endothelial cells. Since thrombin cleaves PAR-1 with
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