Proteasome inhibitor MG-132 induces apoptosis in human acute leukemia Jurkat T cells through mitochondria-dependent caspase pathway that is negatively modulated in the presence of caspase-12 inhibitor (z-ATAD-fmk) or caspase-4 inhibitor (z-LEVD-fmk)

Abstract

Keywords

• proteasome inhibitor;
• MG-132;
• apoptosis;
• mitochondrial cytochrome c;
• endoplasmic reticulum stress;
• caspase cascade;
• Bcl-xL