Proteasome Inhibitor MG-132 Induces Apoptosis in Human Acute Leukemia Jurkat T Cells through Mitochondria-Dependent Caspase Pathway That is Negatively Modulated in the Presence of Caspase-12 Inhibitor (z-ATAD-fmk) or Caspase-4 Inhibitor (z-LEVD-fmk)

Abstract

Keywords

• proteasome inhibitor;
• MG-132;
• apoptosis;
• mitochondrial cytochrome c;
• endoplasmic reticulum stress;
• caspase cascade;
• Bcl-xL