Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)
- 2006.10a
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- Pages.268-268
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- 2006
Evaluation of Porous PLLA Scaffold for Chondrogenic Differentiation of Stem Cells
- Jung, Hyun-Jung (Biomaterials Research Center, KIST) ;
- Park, Kwi-Deok (Biomaterials Research Center, KIST) ;
- Ahn, Kwang-Duk (Biomaterials Research Center, KIST) ;
- Ahn, Dong-June (Dept. of Chem. & Biol. Eng., Korea University) ;
- Han, Dong-Keun (Biomaterials Research Center, KIST)
- Published : 2006.10.13
Abstract
Due to their multipotency, stem cells can differentiate into a variety of specialized cell types, such as chondrocytes, osteoblasts, myoblasts, and nerve cells. As an alternative to mature tissue cells, stem cells are of importance in tissue engineering and regenerative medicine. Since interactions between scaffold and cells play an important role in the tissue development in vitro, synthetic oligopeptides have been immobilized onto polymeric scaffolds to improve specific cell attachment and even to stimulate cell differentiation. In this study, chondrogenic differentiation of stem cells was evaluated using surface-modified PLLA scaffolds, i.e., either hydrophilic acrylic acid (AA)-grafted PLLA or RGD-immobilized one. Porous PLLA scaffolds were prepared using a gas foaming method, followed by plasma treatment and subsequent grafting of AA to introduce a hydrophilicity (PLLA-PAA). This was further processed to fix RGD peptide to make an RGD-immobilized scaffold (PLLA-PAA-RGD). Stem cells were seeded at
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