Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)
- 2006.10a
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- Pages.264-264
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- 2006
Promoted Bone Regeneration by Nanoparticle-Type Sustained Release System of BMP-2 in Hydrogel
- Chung, Yong-Il (Dept of Materials Science and Engineering, GIST) ;
- Lee, Seung-Young (Dept of Materials Science and Engineering, GIST) ;
- Tae, Gi-Yoong (Dept of Materials Science and Engineering, GIST) ;
- Ahn, Kang-Min (Dept of Oral and Maxillofacial Surgery, SNU) ;
- Jeon, Seung-Ho (Dept of Oral and Maxillofacial Surgery, SNU) ;
- Lee, Jong-Ho (Dept of Oral and Maxillofacial Surgery, SNU)
- Published : 2006.10.13
Abstract
The nanoparticle-hydrogel complex as a new bone defect replacement matrix, which is composed of the nanoparticles for the sustained release of BMP and the hydrogel for filling the bone defect site and playing a role as a matrix where new bone can grow, is presented. In vivo evaluation of bone formation was characterized by soft X-ray, MT staining, and calcium assay, based on the rat calvarial critical size defect model. The effective bone regeneration was achieved by the BMP-2 loaded nanoparticles in fibrin gel, compare to bare fibrin gel, the nanoparticle-fibrin gel complex without BMP-2, or the BMP-2 in fibrin gel, in terms of the new bone area and the gray level in X-ray, the bone marrow are, and the calcium content in the initial defect site. These findings suggest that the BMP-2 loaded nanoparticle-fibrin gel complex can a promising candidate for a new bone defect replacement matrix.
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