Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)
- 2006.10a
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- Pages.180-180
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- 2006
Sustained Protein Delivery System using Core/shell Nanoparticles
- Oh, Keun-Sang (Department of Polymer Science and Engineering, Hannam University) ;
- Koo, Hyoung-Mo (Department of Polymer Science and Engineering, Hannam University) ;
- Yuk, Soon-Hong (Department of Polymer Science and Engineering, Hannam University)
- Published : 2006.10.13
Abstract
A novel preparation method for core/shell nanoparticles with protein drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and protein drug and the polymeric shell is composed of Pluronics (poly (ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127 For the application of core/shell nanoparticles as a protein drug carrier, lysozyme and Vascular Endothelial Growth Factor (VEGF) were loaded into the core/shell nanoparticles by electrostatic interaction and the drug release pattern was observed by manipulating the polymeric shell.
Keywords