한국미생물학회:학술대회논문집 (Proceedings of the Microbiological Society of Korea Conference)
- 한국미생물학회 2006년도 International Meeting of the Microbiological Society of Korea
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- Pages.66-68
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- 2006
Structures of SUF Machinery Proteins and their Implications for Iron-Sulfur Cluster Biosynthesis
- Wada, Kei (Department of Biological Sciences, Graduate School of Science, Osaka University) ;
- Hasegawa, Yuko (Department of Biological Sciences, Graduate School of Science, Osaka University) ;
- Kitaoka, Shintaro (Department of Biological Sciences, Graduate School of Science, Osaka University) ;
- Takahashi, Yasuhiro (Department of Biological Sciences, Graduate School of Science, Osaka University) ;
- Fukuyama, Keiichi (Department of Biological Sciences, Graduate School of Science, Osaka University)
- 발행 : 2006.05.03
초록
SUF machinery in Echerichia coli, responsible for the biosynthesis of iron-sulfur clusters, is composed of six protein components (SufABCDSE), among which SufB, SufC, and SufD associate in a complex. We have determined the structures of SufA, SufC, and SufD by X-ray crystallography. SufA is a dimer, in which C-terminal segments containing essential cysteine residues (Cys-Gly-Cys) are positioned to allow coordination of an Fe-S cluster and/or an Fe atom. SufC has the overall structure similar to that of ABC-ATPase but takes an inactive form. SufD has a
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