한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
권호 표지

Characterization of alginate/carboxymethyl scleroglucan hydrogels as a delivery system for protein drug

  • Lee, Chang-Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University) ;
  • Park, Jeong-Eun (Department of Material & Biochemical Engineering, Chonnam National University) ;
  • Kim, Dong-Woon (Department of Health and Hygiene, Gwang-Yang Health College) ;
  • Rhee, Joon-Haeng (Department of Microbiology, Chonnam National University Medical School) ;
  • Kim, Gwang-Yun (Ecobio Inc., Business Incubation Center, Chonnam National University) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National University)
  • Published : 2005.04.15
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to prepare a hydrogels composed of alginate blended with a carboxymethyl scleroglucan (CMSC) and evaluate the feasibility of the hydrogels as a drug delivery system for a protein. The main advantage of the alginate/CMSC hydrogels is to improve a restricted drug release from alginate hydrogels. The CMSC was chemically synthesized with chloroacetic acid and confirmed using a FT-IR. The alginate/CMSC hydrogels were prepared at distinct compositions by crosslinking with calcium ions. The swelling ratios of these hydrogels increased significantly with increasing the content of CMSC. At pH 7.4, the swelling ratios of the hydrogels increased remarkably as compared to those at pH 1.2. In ovalbumin (OVA) release test, the amount of OVA released from the hydrogels showed higher as compared to those released at pH 1.2. In addition, the release of OVA was improved with increasing the content of CMSC. Thus, the alginate/CMSC hydrogels may be used as a potential system for oral delivery of protein drugs.

Keywords