한국원자력학회:학술대회논문집 (Proceedings of the Korean Nuclear Society Conference)

한국원자력학회 (Korean Nuclear Society)
권호 표지

A novel p53-activating radioresponse regulator

  • Jung, Hyun-Ju (Korea Institute of Radiological and Medical Sciences (KIRAMS)) ;
  • Kim, Eun-Hee (Korea Institute of Radiological and Medical Sciences (KIRAMS)) ;
  • Lee, Yun-Sil (Korea Institute of Radiological and Medical Sciences (KIRAMS)) ;
  • Bae, Sang-Woo (Korea Institute of Radiological and Medical Sciences (KIRAMS))
  • 발행 : 2005.05.26
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초록

In order to screen ionizing radiation induced early-response genes, we employed subtractive hybridization method and isolated a metabolism associated gene. The gene expression was very sensitive to ionizing radiation as revealed by a rapid induction of its messenger RNA. We characterized the function of this gene in radiation response. This gene activated p53 and enhanced cell killing effect of ionizing radiation. This effect was attributable to p53 phosphorylation and transcriptional activation.

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