Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 2005.11a
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- Pages.41-63
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- 2005
Protective Effects of Panax ginsengon the Neurotoxicity Induced by Abuse Drugs
- Oh, Ki-Wan (Department of Pharmacy, College of Pharmacy, Chungbuk National University)
- Published : 2005.11.10
Abstract
Ginseng has been useful for the treatment of diverse disease in oriental countries for thousands of years. In addition, a folk medicine prescribed by seven herbal drugs including Panax ginseng has been antinarcotics in the treatment of morphine-dependent patients. Many articles have been reported on these works. Therefore, we review the protective effects of Panax ginseng on the neurotoxicity induced by abuse drugs. Ginseng total saponins (GTS) extracted and isolated by Panax ginseng antagonized morphine-induced analgesia, and inhibited the development of analgesic tolerance to and physical dependence on morphine. CTS inhibited morphine-6 dehydrogenase, which catalyzes production of mophinone from morphine, and increased hepatic glutathione level responsible to toxicity. Therefore, wehypothesized that these dual actions of ginseng can be associated with the detoxication of morphine. In addition, the inhibitory or facilitated effects of GTS on electrically evoked contraction in guinea pig ileum (
Keywords
- Panax ginseng;
- Ginseng Total Saponin;
- Neurotoxicity;
- Abuse Drugs;
- Morphine;
- Cocaine;
- Methamphetamine;
- Analgesic Tolerance;
- Hyperactivity;
- Reverse Tolerance;
- Conditioned Place Preference;
- Physical;
- Psychological Dependence