Mapping Between Models for Pathway Dynamics and Structural Representations of Biological Pathways

  • Yavas, Gokhan (EECS Department, Case Western Reserve University) ;
  • Ozsoyoglu, Z. Meral (EECS Department, Case Western Reserve University)
  • Published : 2005.09.22

Abstract

Mathematical modeling and simulation of biochemical reaction networks gained a lot of attention recently since it can provide valuable insights into the interrelationships and interactions of genes, proteins and metabolites in a reaction network. A number of attempts have been made for modeling and storing biochemical reaction networks without their dynamical properties but unfortunately storing and efficiently querying of the dynamic (mathematical) models are not yet studied extensively. In this paper, we present a novel nested relational data schema to store a pathway with its dynamic properties. We then show how to make the mapping between this dynamic pathway schema with the corresponding static pathway representation.

Keywords