한국생물정보학회:학술대회논문집 (Proceedings of the Korean Society for Bioinformatics Conference)
- 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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- Pages.395-398
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- 2005
Evaluation of Methods to Analyze SNP-based Association Studies in a DNA-Pooling Experiment with Preferential Amplification
- Ahn, Chul (Department of Medicine, University of Texas Medical School) ;
- Lee, Kyu-Sang (Samsung Advanced Institute of Technology)
- 발행 : 2005.09.22
초록
Genetic association case-control studies using DNA pools are efficient ways of detecting association between a marker allele and disease status. DNA pooling is an efficient screening method for locating susceptibility genes associated with the disease. However, DNA pooling is efficient only when allele frequency estimation is done precisely and accurately. Through the evaluation of empirical type I errors and empirical powers by simulation, we will evaluate the methods that correct for preferential amplification of nucleotides when estimating the allele frequency of single-nucleotide polymorphisms.
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