한국식물생명공학회:학술대회논문집 (Proceedings of the Korean Society of Plant Biotechnology Conference)
- 한국식물생명공학회 2004년도 생명공학 실용화를 위한 비젼
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- Pages.74-79
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- 2004
Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells
- Kim, Shi-Yeon (Department of Physiology, College of Medicine, The Catholic University of Korea) ;
- Min, Kyoung-Jin (Department of Pharmacology, Ajou University) ;
- Joe, Eun-Hye (Department of Pharmacology, Ajou University) ;
- Min, Do-Sik (Department of Physiology, College of Medicine, The Catholic University of Korea)
- 발행 : 2004.10.22
초록
Little is known about the effect of epigallocatechin-3 gallate (ESCG), a major constituent of green tea, on the expression of cyclooxygenase (COX)-2. Here, we studied the role of phospholipase D (PLD) isozymes in EGCG-induced COX-2 expression. Stimulation of human astrocytoma cells (U87) with EGCG induced formation of phosphatidylbutanol, a specific product of PLD activity, and synthesis of COX-2protein and its product, prostaglandin