Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 2004.11a
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- Pages.50-61
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- 2004
Plasma Membrane Transporters for Lead and Cadmium
- Bressler Joseph P. (Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Kennedy-Krieger Institute) ;
- Olivi Luisa (Kennedy-Krieger Institute) ;
- Cheong Jae Hoon (School of Pharmacy, Sahmyook University) ;
- Kim Yongbae (Department of Preventive Medicine, Soonchunhyan University) ;
- Bannon Desmond (US Army, Aberdeen Proving Ground)
- Published : 2004.11.01
Abstract
Lead and cadmium are potent environmental toxicants that affect populations living in Europe, Americas, and Asia. Identifying transporters for lead and cadmium could potentially 1 help us better understand possible risk factors. The iron transporter divalent metal transporter 1(DMT1) mediates intestinal transport of cadmium, and lead in yeast and fibroblasts overexpressing DMT1. In human intestinal cells knocking down expression of DMT1 attenuated uptake of cadmium and iron but not lead. A possible explanation is the expression of a second transporter for lead in intestine. In astrocytes, however, DMT1 appears to transport lead in an extracellular buffer at pH value. At neutral pH, transport was not mediated by DMT1 but rather by a transporter that is stimulated by bicarbonate and inhibited by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid. The identity of this lead transporter is under study.
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