Soft Lithographic Patterning of Hyaluronic Acid on Hydrophilic Substrates using Molding and Printing

  • Suh, Kahp Y. (School of Mech. and Aerospace Eng., Seoul Natinal Univ.) ;
  • Khademhosseini, Ali (Division of Biological Eng. Massachusetts Institute of Engineering) ;
  • Yang, Jen Ming (Department of Cheical and Materials Engineering, Chang Gung University) ;
  • Eng, George (Division of Biological Eng. Massachusetts Institute of Engineering) ;
  • Langer, Robert (Division of Biological Eng. Massachusetts Institute of Engineering)
  • Published : 2004.11.27

Abstract

In summary, we have demonstrated soft lithographic application of HA (or polysaccharides in general) by means of ${\mu}CP$ and molding and constructed well-defined patterns of proteins and cells of various substrates including glass, silicon dioxides, poly(HEMA), polystyrene culture dishes, and biodegradable PLGA. These results suggest that HA could be used as a general platform on hydrophilic substrates.

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