혈액투석 중 심혈관계 응답의 수치적 연구

Simulation Study of Cardiovascular Response to Hemodialysis

The object of this study is to develop a model of the cardiovascular system capable of simulating the short-term transient and steady-state hemodynamic responses such as hypotention and disequilibrium syndrome during hemodialysis or hemofiltration. The model consists of a closed loop 12 lumped-parameter representation of the cardiovascular circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes and 3 compartmental body fluid and solute kinetic model. The hemodialysis model includes the dynamics of sodium, urea, and potassium in the intracellular and extracellular pools, fluid balance equations for the intracellular, interstitial, and plasma volumes. We have presented the results of many different simulations performed by changing a few model parameters with respect to their basal values.