Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)
- 2004.06a
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- Pages.215-215
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- 2004
Human Keratin 14 Driven HPV 16 E6/E7 Transgenic Mice Exhibit Hyperkeratinosis
- Kim, Sung-Hyun (Catholic Research Institutes of Medical Science, Catholic University, Department of Animal Science, Graduate School of Konkuk University) ;
- Kim, Kil-Soo (Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University) ;
- Lee, Eun-Ju (Catholic Research Institutes of Medical Science, Catholic University) ;
- Kim, Myoung-Ok (Catholic Research Institutes of Medical Science, Catholic University) ;
- Park, Jun-Hong (Catholic Research Institutes of Medical Science, Catholic University) ;
- Cho, Kyoung-In (Catholic Research Institutes of Medical Science, Catholic University) ;
- Kazuhiko-Imakawa (Laboratory of Animal Breeding, Faculty of Agriculture, The University of Toky) ;
- Hyun, Byung-Hwa (Laboratory of Primate Research, Korea Research Institute of Bioscience & Biotechnolog) ;
- Chang, Kyu-Tae (Laboratory of Primate Research, Korea Research Institute of Bioscience & Biotechnology) ;
- Lee, Hoon-Taek (Department of Animal Science, Graduate School of Konkuk University) ;
- Ryoo, Zae-Young (Catholic Research Institutes of Medical Science, Catholic University)
- Published : 2004.06.01
Abstract
Human papillomavirus type 16 (HPV16) has been known as a major causative factor for the development of uterine cervical carcinomas. To investigate the in vivo activity of HPV16 expressed in squamous epithelia, transgenic mice harboring HPV16 E6/E7 with human keratin 14 (hK14) promoter were generated. Grossly, hK14 driven HPV16 E6/E7 transgenic mice exhibited multiple phenotypes, including wrinkled skin that was apparent prior to the appearance of hair in neonates, thickened ears, and loss of hair in adults. (omitted)