Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)

The Korean Society of Animal Reproduction (한국동물번식학회)
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Production of Transgenic Pig Harboring Tissue-type Plasminogen Activator Gene with Bovine-$\beta$-Casein Promoter

  • Park, J.K. (Division of Animal Biotechnology, National Livestock Research Institute, RDA) ;
  • Lee, Y.K. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Lee, P.Y. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Kim, S.W. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Jeon, I.S. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Lee, H.G. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Han, J.H. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Park, C.G. (Division of Animal Biotechnology, National Livestock Research Institute, RD) ;
  • Lee, S.E. (Division of Animal Biotechnology, National Livestock Research Institute, RDA) ;
  • Beak, K.N. (Division of Animal Biotechnology, National Livestock Research Institute, RDA) ;
  • Chang, W.K. (Division of Animal Biotechnology, National Livestock Research Institute, RDA)
  • Published : 2004.06.01
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Abstract

Tissue plasminogen activator (tPA) plays important roles in the brain after excitotoxic injury. This study was conducted to produce transgenic pig harboring human tissue plasminogene activator (htPA) gene. Recombinent htPA(rhtPA) genes containing bovine-β-casein promoter (bBC) were prepared for microinjection and testified the expression level of htPA protein from the Chinese hamster ovary (CHO) cell lines before NDA microinjection into the porcine pronuclei. (omitted)

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