한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2004년도 Annual Meeting of KSAP : New Drug Development from Natural Products
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- Pages.3-10
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- 2004
Pharmacology of enantiomers of higenamine and related tetrahydroisoquinolines
- Park, Min-Kyu (Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
- Huh, Ja-Myung (Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
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Lee, Young-Soo
(Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
- Kang, Young-Jin (Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
- Seo, Han-Geuk (Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
- Lee, Jae-Heun (Department of Pharmacology, College of Medicine, Gyeongsang National University) ;
- Park, Hye-Sook-Yun- (Natural Product Research Institute, Seoul National University) ;
- Lee, Duck-Hyung (Department of Organic Chemistry, Sogang University) ;
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Chang, Ki-Churl
(Department of Pharmacology, College of Medicine, Gyeongsang National University)
- 발행 : 2004.04.01
초록
Oxidative stress is a constant threat to all living organisms and an immense repertoire of cellular defense systems is being employed by most pro- and eukaryotic systems to eliminate or to attenuate oxidative stress. Ischemia and reperfusion is characterized by both a significant oxidative stress and characteristic changes in the antioxidant defense. Heme oxigenase-l (HO-l) is up-regulated by various stimuli including oxidative stress so that it is thought to participate in general cellular defense mechanisms against ischemic injury in mammalian cells. Higenamine, an active ingredient of Aconite tuber, has been shown to have antioxidant activity along with inhibitory action of inducible nitric oxide synthase (iNOS) expression in various cells. In the present study, we investigated whether higenamine and related analogs protect cells from oxidative cellular injuries by modulating antioxidant enzymes, such as HO-l, MnSOD etc. R-form of YS-51 was the most potent inducer of HO-l in bovine endothelial cells, which inhibited apoptotic cell death by H