한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
권호 표지

A Study on the Extraction and Efficacy of active ingredient from Hovenia dulics

  • Kim, Seong-Mun (Biochemical Engineering Laboratory, Department of Chemical Engineering, Kongju National University) ;
  • Kim, Jin-Hyun (Biochemical Engineering Laboratory, Department of Chemical Engineering, Kongju National University)
  • Published : 2003.10.22
Download PDF
⟨ Previous Next ⟩

Abstract

The water extracts of Hovenia dulcis Thunb. showed significant reducing alcohol concentration in blood and hepatoprotective acitivity against D-galactoseamine/LPS and CCl4-toxicity. The concentration of blood alcohol was decreased from 2hr after injected in rats with Hovenia dulcis extracts. The water extracts of Hovenia dulcis significantly inhibited the elevation of serum ALT, AST and LDH levels. In this study, we investigated the effect of Hovenia dulcis extract on reducing alcohol concentration in blood. Also the efficacy and toxicity of Hovenia dulcis extract were evaluated by in vivo and in vitro tests.

헛개나무 열매, 잎 및 줄기를 부위별로 열수 추출한 추출액의 알코올 분해 효과를 관찰한 결과 6hr인 경우, 헛개열매의 알코올 분해 효과가 38% 증가하였고 6hr 이후에는 평형에 도달함을 알 수 있었다. $D-galactosamine(600{\mu}g/kg)/LPS(60{\mu}g/kg)$와 $CCl_4(1.0m{\ell}/kg)$를 처리한 후 헛개열매 열수 추출물을 투여한 결과 간 기능 수치인 AST, ALT 및 LDH 값이 상당히 감소함을 알 수 있었다. 급성독성 시험과 아급성독성 시험에서도 헛개열매 추출물이 안정한 물질로 작용하는 것을 알 수 있었다.

Keywords