한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Implantation of bone marrow mononuclear cells using fibrin gels enhances neovascularzation in ischemia myocardium

  • Ryu, Ju-Hee (Department of Chemical Engineering, Hanyang University, School of Chemical Engineering, Seoul National University) ;
  • Kim, Il-Kwon (Brain Korea 21 project for Medical Science, Yonsei University College of Medicine) ;
  • Cho, Seung-Woo (Department of Chemical Engineering, Hanyang University, School of Chemical Engineering, Seoul National University) ;
  • Cho, Myeong-Chan (Department of Cardiology, College of Medicine, Chungbuk National University) ;
  • Hwang, Kyung-Kuk (Department of Cardiology, College of Medicine, Chungbuk National University) ;
  • Piao, Shuguang (Department of Cardiology, College of Medicine, Chungbuk National University) ;
  • Piao, Hainan (Department of Cardiology, College of Medicine, Chungbuk National University) ;
  • Lim, Sang-Hyun (Cardiovascular Center, Yonsei University College of Medicine) ;
  • Yoo, Kyung-Jong (Cardiovascular Center, Yonsei University College of Medicine) ;
  • Hong, Yoo-Sun (Cardiovascular Center, Yonsei University College of Medicine) ;
  • Choi, Cha-Yong (School of Chemical Engineering, Seoul National University) ;
  • Kim, Byung-Soo (Department of Chemical Engineering, Hanyang University)
  • Published : 2003.10.22
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Abstract

Despite recent advances in the treatment of acute myocardial infarction, the ability to repair extensive myocardial damage is limited. Revascularization in ischemic myocardium is required to improve cardiac function and prevent further scar tissue formation. Bone marrow contains endothelial precursors that can be used to induce neovascularization in ischemic myocardium. To develop a new therapy for myocardial infarction, we investigated if implantation of bone marrow mononuclear cells (BM-MNCs) using biodegradable matrices could enhance neovascularization in ischemic myocardium. Eight weeks after implantation, the damaged myocardium implanted with BM-MNCs and fibrin gels exhibited significantly greater angiogenic responses than those implanted with either fibrin gels or BM-MNCs alone. Fibrin gels disappeared completely 8 weeks after implantation. Echocardiography revealed improved heart functions. These results suggest that implantation of BM-MNCs using fibrin gel matrix efficiently induces neovascularization and improved heart functions in ischemic myocardium.

본 연구에서는 손상된 심근의 재생을 위하여 골수단핵세포를 피브린 고분자와 함께 SD 래트에 이식하였고 8주 후에 신생혈관의 형성과 더불어 심장의 기능이 향상되었음을 확인할 수 있었다. 이 연구는 세포이식을 통한 조직 재생시 세포 이식용 매트릭스의 중요성을 보여준다. 환자 자신의 골수세포를 사용한다면 면역 문제가 없어서, 이 방법이 심부전 환자의 치료에 쉽게 이용될 수 있을 것이다.

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