한국생물공학회:학술대회논문집
- 한국생물공학회 2003년도 생물공학의 동향(XII)
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- Pages.733-735
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- 2003
Molecular analysis on the ODC antizyme from flounder (Parlichthys olivaceus)
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Seo, Yong-Bae
(Department of Microbiology, Pukyong National University) ;
- Lee, Jae-Hyung (Department of Microbiology, Pukyong National University) ;
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Kim, Young-Tae
(Department of Microbiology, Pukyong National University)
- 발행 : 2003.04.11
초록
Ornithine decarboxylase (ODC) is a key enzyme on the regulation of cellular polyamines. ODC antizyme is a protein that represses ODC through accelerating enzymatic degradation by the 26S proteasome. We have isolated two distinct antizyme cDNA clones (AZS and AZL) from a brain cDNA library constructed with flounder (Paralichthys olivaceus). AZS and AZL cDNA clones were encoding 221 and 218 residues long respectively and revealed 57.7% amino acids sequence identity. The presence of two antizymes mRNA were detected in brain, kidney, liver, and embryo.
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