한국생물공학회:학술대회논문집
- 한국생물공학회 2003년도 생물공학의 동향(XII)
- /
- Pages.223-227
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- 2003
Improved mevinolic acid (MA) production by the immobilized cells, and the establishment of on-line measurement system for fermentation parameters using vent gas analyzer
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송성기
(강원대학교 생명과학부) ;
- 김경희 (강원대학교 생명과학부) ;
- 김명진 (강원대학교 생명과학부) ;
-
이상종
((주)에스티알바이오텍) ;
-
장용근
(KAIST 생명화학공학과) ;
- 정연호 (강원대학교 생명공학부) ;
-
정용섭
(전북대학교 응용생물공학부) ;
-
전계택
(강원대학교 생명과학부)
-
Song, Seong-Gi
;
- Kim, Gyeong-Hui ;
- Kim, Myeong-Jin ;
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Lee, Sang-Jong
;
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Jang, Yong-Geun
;
- Jeong, Yeon-Ho ;
-
Jeong, Yong-Seop
;
-
Jeon, Gye-Taek
- 발행 : 2003.04.11
초록
Mevinolic acid (MA), a secondary metabolite produced by a filamentous fungus Aspergillus terreus, is acidic form of lovastatin which has been identified as a powerful cholesterol-lowering agent in humans. When immobilized cell culture was performed, MA production was about 5.3-fold higher than the parallel suspended cell culture. Although the immobilized cells proliferated slowly during exponential in comparison with the suspended cells, oxygen uptake rate and oxygen mass transfer coefficient of the immobilized cell culture were about 1.3- and 2.5- fold higher respectively than those of the parallel suspended cell culture. From these results, it was concluded that MA biosynthesis was closely dependent on the cell growth rate, morphology and oxygen availability.
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