Proceedings of the Korean Institute of Resources Recycling Conference (한국자원리싸이클링학회:학술대회논문집)
- 2003.10a
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- Pages.196-200
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- 2003
Development of Separation Process for Active Ingradient from Waste Biomass
폐 바이오매스로부터 생리활성물질의 분리공정 개발
- Sung, Ju-Li (Department of Chemical Engineering, Kongju National University) ;
- Kim, Seong-Mun (Department of Chemical Engineering, Kongju National University) ;
- Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
- Published : 2003.10.15
Abstract
A novel prepurification method was developed aiming at increasing yield and purity, also reducing solvent usage for purification of paclitaxel. The use of a micelle and precipitation in the prepurification process allows for rapid separation of paclitaxel from interfering compounds and dramatically reduces solvent usage compared to alternative methodologies. The prepurification process serves to minimize the size and complexity of the HPLC operations for paclitaxel purification. The process is readily scalable to a pilot plant and eventually to a production environment where multikilogram quantities of material are expected to be produced. As much as possible, the process has been optimized to minimize solvent usage, complexity, and operating costs.