Detecting differentially expressed genes from a mixed data set

  • Lee, Sun-Ho (Department of Applied Mathematics, Sejong University) ;
  • Kim, In-Young (Cancer Metastasis Research Center, Yonsei University College of Medicine) ;
  • Kim, Sang-Cheol (Cancer Metastasis Research Center, Yonsei University College of Medicine) ;
  • Rha, Sun-Young (Cancer Metastasis Research Center, Yonsei University College of Medicine) ;
  • Chung, Hyun-Chel (Cancer Metastasis Research Center, Yonsei University College of Medicine) ;
  • Kim, Byung-Soo (Department of Applied Statistics, Yonsei University)
  • Published : 2003.10.31

Abstract

When we have both a paired data set and two independent data sets, neither a paired t-test nor a two-sample t-test can be used to detect differences between two samples. In order to identify differentially expressed genes in a mixed data set, a new test statistic is proposed.

Keywords