Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Retrospective Evaluation of Heptaplatin Nephrotoxicity in Patients with Advanced Gastric Cancer

  • Park, Mi-Sook (Chungbuk National University, College of Pharmacy, and Research Center for Bioresource and Health) ;
  • Kang, Min-Hee (Chungnam National University Hospital, Deparment of Pharmac) ;
  • Choi, Sun-Ok (Chungnam National University Hospital, Deparment of Pharmac) ;
  • Chang, Sun-Mee (Chungnam National University Hospital, Deparment of Pharmac) ;
  • Kim, Jun-Cheol (Chungnam National University Hospital, Deparment of Pharmac) ;
  • Lee, Myung-Koo (Chungnam National University Hospital, Deparment of Pharmacy)
  • Published : 2003.10.01
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Abstract

There are contradicting reports on the nephrotoxicity of heptaplatin, a new platinum derivative. A retrospective study was performed to compare the toxicities of heptaplatin-containing regimens with the ones not. Seventy-seven patients with advanced gastric cancer who did not receive any chemotherapy within the last 3 months before the treatment were evaluated. Among them 38 patients received heptaplatin-containing regimens (heptaplatin/epirubicin/5-FU: 26, heptaplatin/5-FU: 12) and 39 patients received other regimens (cisplatin/epirubicin/5-FU:11, epirubicin/leucovorin/5-FU: 28). (omitted)

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