대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.247.2-247.2
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- 2003
Transdermal and topical LMWH delivery from ultradeformable and other vesicles: Characterization and in vitro and vivo permeation studies
- Hyun, Myung-Ja (College of pharmacy, Seoul National University) ;
- Park, Jeong-Sook (College of pharmacy, Seoul National University) ;
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Kim, Chong-Kook
(College of pharmacy, Seoul National University)
- 발행 : 2003.10.01
초록
To increase skin permeability of LMWH (Low Molecular Weight Heparin), ultradeformable liposomes were developed. Ultradeformable liposomes were developed by Egg phosphatidylcholine (Egg-PC) and edge activator. Entrapment efficiency, vesicle size and zeta potential of vesicles were determined and characterized for deformability and stability. Transepidermal permeation of LMWH was compared to saturated aqueous control in vitro. The steady-state flux and its maximum time were calculated from the flux curves. (omitted)
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