Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.244.2-244.2
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- 2003
Pharmacokinetic disposition of apicidin possessing histone deacetylase inhibiting activities
- Shin, Beom-Soo (College of pharmacy, Sungkyunkwan University) ;
- Jun, Yoon-Sik (College of pharmacy, Sungkyunkwan University) ;
- Kim, Chul-Hwan (College of pharmacy, Sungkyunkwan University) ;
- Yoo, Sun-Dong (College of pharmacy, Sungkyunkwan University)
- Published : 2003.10.01
Abstract
The objective of this study was to characterize the absorption and pharmacokinetic disposition of novel cyclic tetrapeptide, apicidin, in rats. Apicidin was administered to SD rats by i.v. bolus injection (1,2 or 4 mg/kg) and oral gavages (10 mg/kg). Serum levels of apicidin were monitored by LC/MS over 8 hours following each administration. Upon i.v. injection, serum levels of apicidin were best fit by a multi-exponential equation. The t
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