$\textrm{Dompi}^{?}$" Tablets Containing Domperidone Maleate in Healthy Korean Volunteers"> Bioequivalence Assessment of Shinpoong "$\textrm{Dompi}^{?}$" Tablets Containing Domperidone Maleate in Healthy Korean Volunteers

  • Published : 2003.10.01

Abstract

The bioequivalence of two tablet formulations of 12.72 mg domperidone maleate (Shinpoong "$\textrm{Dompi}^{?}$" tablets vs. Janssen Korea "$\textrm{Dompi}^{?}$" tablets) was assessed in healthy Korean volunteers after oral administration in a randomized crossover study. Blood samples were collected at specified time intervals, and plasma concentration was measured as the amount of domperidone base using a validated HPLC method. The pharmacokinetic parameters of $AUC_{0{\longrightarrow}48}$, $C_{max}$, $T_{max}$$t\frac{1}{2}$ were determined from plasma concentration-time profile of two formulations. (omitted)

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