Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.238.1-238.1
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- 2003
Effect of Rhus verniciflua strokes acetone extracts and its components on the proliferation, collagen synthesis, and hepatic fibrosis related proteins mRNA levels in rat hepatic stellate cells
- Hyun, Jung-Seung (School of Life Sciences and Biotechnology, Korea University) ;
- Kim, Jeong-Ran (Lifetree Biotech Co.Lt) ;
- Na, Chun-Soo (Lifetree Biotech Co.Lt) ;
- Choi, Bum-Rak (Lifetree Biotech Co.Lt) ;
- Yoon, Sun-Young (Lifetree Biotech Co.Lt) ;
- Park, Young-In (Lifetree Biotech Co.Lt) ;
- Dong, Mi-Sook (Lifetree Biotech Co.Ltd)
- Published : 2003.10.01
Abstract
Hepatic stellate cells (HSC) and the derived myofibroblasts are known to play a central role in liver fibrogenesis. Rhus verniciflua Strokes (RVS) has traditionally been used in Korea herbal medicine for a stomachic tonic. In this study, we observed the effect of RVS acetone extract (Ra) and its five major components on the proliferation, the collagen synthesis, and hepatic fibrosis related proteins mRNA levels in HSC-T6 cells which is a fully activated rat hepatic stellate cell line. Ra inhibited the proliferation and decreased the content of collagen in the HSC-T6 cells. (omitted)
Keywords