대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.237.1-237.1
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- 2003
Anti-gelling Effect of Poly(methacrylic acid, methyl methacrylate) on Cefuroxime Axetil Composition
- Shim, Ji-Yeon (GL PharmTech Corp.) ;
- Wang, Hun-Sik (GL PharmTech Corp) ;
- Kwon, Min-Chang (GL PharmTech Corp) ;
- Park, Jun-Sang (GL PharmTech Corp.)
- 발행 : 2003.10.01
초록
Cefuroxime axetil, a broad spectrum antibiotic, has been known to form a gelatinous mass in contact with aqueous media, which could lead to poor dissolution. Therefore, this study was conducted for removing the gelling phenomenon and thereby obtaining a favorable dissolution profile. We have found that the addition of poly (methacrylic acid, methyl methacrylate) could not only inhibit the tendency of cefuroxime axetil to form a gel but also showed the good dissolution profile compared to the formula without poly (methacrylic acid, methyl methacrylate). (omitted)
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