Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Chitosan surface grafted with fusion protein of FGF-2 and Fibronectin-FGF for tissue regeneration therapy

  • Hwang, Jeong-Hyo (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Lee, Jue-Yeon (Intellectual Biointerface Engineering Cente) ;
  • Kim, Sun-Chul (Department of Periodontology, College of Dentistry, DRI, Seoul National University) ;
  • Jang, Jun-Hyeog (Department of Periodontology, College of Dentistry, DRI, Seoul National University) ;
  • Ku , Young (Department of Periodontology, College of Dentistry, DRI, Seoul National University) ;
  • Chung, Chong-Pyoung (Department of Periodontology, College of Dentistry, DRI, Seoul National University) ;
  • Lee, Seung-Jin (Department of Periodontology, College of Dentistry, DRI, Seoul National University)
  • Published : 2003.10.01
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Abstract

The biomedical applications of chitosan have been widely researched. FN mediates its biological effects through binding to the hetero-dimeric transmembrane glycoproteins, integrins, which physically couple the cytoskeleton to the ECM. FN binds to the integrin through a consensus site including the Arg-Gly-Asp (RGD) sequence within tenth type III module (Ruoslahti & Pierschbacher 1987). A short sequence Pro-His-Ser-Arg-Asn (PHSRN) has also been identified as a synergistic motif within ninth type III module for binding to ${\alpha}$5${\beta}$1 integrin (Aota et al. 1994). (omitted)

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