Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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In Vitro Release of Acetaminophen from Mucoadhesive Microsphere Prepared by Poly(acrylic acid)/poly(vinyl pyrrolidone) Interpolymer Complex

  • Chun, Myung-Kwan (Chosun University, College of Pharmacy) ;
  • Cho, Chong-Su (School of Agricultural Science and Biotechnology, Seoul National University) ;
  • Choi, Hoo-Kyun (School of Agricultural Science and Biotechnology, Seoul National University)
  • Published : 2003.10.01
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Abstract

Mucoadhesive microsphere was prepared by interpo]ymer complexation of po]y(acrylic acid) (PAA) with po]y(vinyl pyrrolidone) (PVP) using solvent diffusion method. The loading efficiency of acetaminophen into the microsphere was 91.3 ${\pm}$ 6.5%. The release rate of acetaminophen from the PAA/PVP complex microspheres was slower than that from PVP microspheres at pH 2.0 and 6.8. The dissolution of microspheres made of the complex was significantly slower than those made of PVP due to H-bond between PVP and PAA. As a result, the release rate of acetaminophen from the complex microspheres was slower than that from PVP microspheres.

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