Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Micro-and nanofibrous scaffold for enhanced cartilage regeneration

  • Lee, Myung-Hee (Department of Pharmacy, Ewha Womans University) ;
  • Shim, In-Kyong (Department of orthopedic surgery, Seoul National University) ;
  • Hwang, Jung-Hyo (Department of orthopedic surgery, Seoul National University) ;
  • Ahn, Hyun-Jung (Department of orthopedic surgery, Seoul National University) ;
  • Lee, Sang-Hoon (Department of orthopedic surgery, Seoul National University) ;
  • Lee, Myung-Chul (Department of orthopedic surgery, Seoul National University) ;
  • Lee, Seung-Jin (Department of orthopedic surgery, Seoul National University)
  • Published : 2003.10.01
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Abstract

Extracellular matrix(ECM) is composed of the ground materials(proteoglycan) and nano size diameter fibrous proteins(ex. collagens) that together form a composite-like structure. In this study, fibrous scaffold with biomimetic architecture based on collagen nanofibers interpenetrated in PLGA/chitosan microfibrous matrix. Chitosan was selected for its structure similarity to glycosaminoglycan and neutralizing capacity for PLGA acidic metabolite. Collagen nanofiber were prepared by electrospinning. (omitted)

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