Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.226.3-227
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- 2003
Intravenous and Intra-arterial Delivery of Plasmid DNA/Cationic Lipiodol Emulsion Complexes
- Chae, Min-Jung (Biomedical Research Center, Korea Institute of Science and Technology) ;
- Chung , Hes-Son (Dept. of Pharmacy, Duksung Women's University) ;
- Kwon, Ick-Chan (Biomedical Research Center, Korea Institute of Science and Technolog) ;
- Chung, Jin-Wook (Dept. of Radiology, College of Medicine, Seoul National University) ;
- Park, Jae-Hyung (Dept. of Pharmacy, Duksung Wome's University) ;
- Sohn, Young-Taek (Dept. of Pharmacy, Duksung Wome's University) ;
- Jeong, Seo-Young (Dept. of Pharmacy, Duksung Wome's University)
- Published : 2003.10.01
Abstract
A cationic lipid emulsion (o/w) containing lipiodol and 1, 2-dioleoyl-sn- glycero-3-trimethylammonium-propane (DOTAP) has been prepared as a gene delivery system. In order to increase the transfection efficiency of the lipiodol emulsion, 1 2-dioleoyl-sn-glycero-3-phospho-ethanolamine (DOPE) and polyoxyethylene sorbitan monooleate (Tween 80) were incorporated as additional lipids. By including DOPE and Tween 80, the cationic emulsion became a more potent gene carrier under in vitro condition in the presence of serum, and under in vivo condition. (omitted)
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