Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.224.3-225
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- 2003
Skin penetration enhancement of prostaglandin El and its ethyl ester for topical formulations
- Kim, Hee-Kyu (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
- Kim, Jong-Seok (GUJU Pharma CO. LT) ;
- Yang, Sung-Woon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
- Choi, Han-Gon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
- Yong, Chul-Soon (Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756) ;
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Choi, Young-Wook
(Department of Immunology, College of Pharmacy, Chung-Ang University, Seoul 156-756)
- Published : 2003.10.01
Abstract
Purpose. To investigate the effect of different terpene enhancers on skin penetrations of prostaglandin El (PGE1) and its ethyl ester (PGE1-EE), a therapeutic agent for erectile dysfunction, external gel systems were formulated with the specific enhancers having different values in their lipophilicity (log P was ranged in 2.23-4.58). Methods. Topical gels containing PGEl (0.5 %) and PGEl-EE (0.1 %) were formulated with ethanol and propylene glycol as a vehicle, selective terpenes as a penetration enhancer, and HPC-H as a thickening agent. (omitted)
Keywords