Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.223.2-223.2
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- 2003
Determination of Eupatilin in Human Plasma by Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry
- Lee, Hye-Won (College of Pharmacy, Wonkwang University) ;
- Ji, Hye-Young (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
- Kim, Hui-Hyun (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
- Kim, Sook-Jin (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
- Kim, Soon-Hoe (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
- Kim, Won-Bae (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905) ;
- Lee, Hye-Suk (Dong-A Pharmaceutical Co. LTD, 47-5, Sanggal-ri, Kiheung-up. Yongin-si, Kunggi-do,449-905)
- Published : 2003.10.01
Abstract
A rapid, sensitive and selective liquid chromatography-tandem mass spectrometric (LC/MS/MS) method for the determination of eupatilin in human plasma was developed. Eupatilin and internal standard, (S)-[N-3-(4-(2-(1-methyl-5-tetrazolyl)-pyridine-5-y1)- 3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide (DA-7867) were extracted from human plasma by liquid-liquid extraction and analyzed on a phenyl-hexyl column with the mobile phase of acetonitrile-ammonium formate (10 mM, pH 3.0) (60:40, v/v). (omitted)
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