Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The Role of Sphingolipids Cycle in Hydrogen Peroxide-Induced Apoptosis in HL-60 Cells

  • Son , Jung-Hyun (Korea Institute of Science and Technology, Bioanalysis and Biotransformation Research Center) ;
  • Lee, Jae-Ick (Yonsei University, Department of Biotechnolog) ;
  • Yang , Ryung (Yonsei University, Department of Biotechnolog) ;
  • Kim, Dong-Hyun (Yonsei University, Department of Biotechnology)
  • Published : 2003.10.01
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Abstract

Sphingolipids and their metabolites are highly bioactive molecules that affect various cellular functions including differentiation, cellular senescence, apoptosis, and proliferation when added exogenously, or elevated intracellularly by turnover of complex sphingolipids or synthesis from de novo pathway. We are investigating the relationship of sphingolipids cycle in apoptosis early events. A new column liquid chromatography- tandem mass spectrometry (LC/MS/MS) in combination with multiple reaction monitoring (MRM) method was developed for the rapid, simultaneous and quantitative determination of unambiguous detecting sphingolipids in cells. (omitted)

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