The Effects of Scutellaria baicalensis and Scutellaria baicalensis metabolite on Anxiety in the Elevated Plus-Maze in Rats

  • Jung, Ji-Wook (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ahn, Nam-Yoon (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Oh, Hye-Rim (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Park, Sung-Hwan (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Oh, Jin-Kyung (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee, Bo-Kyung (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Dong-Hyun (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu, Jong-Hoon (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University)
  • Published : 2003.10.01

Abstract

Scutellaria baicalensis Georgi is one of the most important medicinal herbs in traditional chinese medicine. The object of this study was to determine the effects of water extracts of Scutellaria baicalensis (SB) and Scutellaria baicalensis metabolite (SBM) on the anxiolytic-like activities in the elevated plus-maze (EPM) test. The water extracts of SB (100, 200, or 400 mg/kg), and SBM (100 mg/kg) were orally administered to male SD rats for 3 day. All rats were subjected to behavioral tests for the anxiolytic activity at 3 days. (omitted)

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