Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.210.2-210.2
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- 2003
Cytotoxic Effects of Chloroform Extracts and Fraction from Cornis fructus on Cancer Cell Lines
- Hyun, Ja-Chun (Division of Natural Science and Technology) ;
- Choi, Won-Hyung (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
- Seung, Hwa-Baek (Professional Graduate School of Oriental Medicine, Wonkwang University)
- Published : 2003.10.01
Abstract
Cornis fructus were extracted by successive extractions and then fractionated with chloroform extract to get active fractions. This study was performed to determine the cytotoxic effect of chloroform extract from Cornis fructus on NIH 3T3 fibroblasts and cancer cell lines using MTT assay. All extracts did not exhibit cytotoxicity in HIH 3T3 fibroblasts. Chloroform extract exhibited antitumor activity in A549, MDA-MB-123, B16 melanoma and SNU-C4 cells. Futher fractionation with chloroform extract was performed to obtain effective fractions. (omitted)
Keywords