Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Cholinesterase-inhibitory Farnesylacetone Derivatives from the Brown Alga Sargassum sagamianum

  • Park, Soo-Hee (Dept. of Chemical Technology, Hanbat National University) ;
  • Hwang, Jeong-Won (Dept. of Chemical Technology, Hanbat National University) ;
  • Lee, Bong-Ho (Dept. of Chemical Technology, Hanbat National University) ;
  • Choi, Byoung-Wook (Dept. of Chemical Technology, Hanbat National University) ;
  • Ryu, Geon-Seek (Dept. of Chemical Technology, Hanbat National University)
  • Published : 2003.10.01
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Abstract

In continuing search for bioactive compounds from Korean marine algae, we found cholinesterase-inhibitory activity in the methanolic extract of brown alga Sargassum sagamianum. After partitioning between CHCl$_3$ and 30% MeOH, the former layer was purified by a series of ODS flash, silica column, gel-filtration on Sephadex LH-20, and HPLC to give two farnesylacetone derivatives. Their structures were identified by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with IC$\sub$50/ values of 65.0∼48.0 ${\mu}$M and 34.0∼23.0 ${\mu}$M, respectively. (omitted)

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