Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Antitumor flavonoids from Cephalotaxus koreana Nakai

  • Jin, Wen-Yil (College of Pharmacy, Chungnam National University, Daejeon 305-764) ;
  • Song, Gyu-Yong (College of Pharmacy, Chungnam National University, Daejeon 305-764) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University, Daejeon 305-764) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Phamzacy, Wonkwang University, Cheonbuk 540-749) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University, Daejeon 305-764)
  • Published : 2003.10.01
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Abstract

Cephalotaxus koreana Nakai is an endemic species in Korea. The EtOH extract of leaf and branch from the plant showed potent antitumor activity in Teruhiro's method. The tumor volume inhibition ratio value is 25.2% with 20mg/kg in the BDF1 mouse injected LLC cell. We isolated one flavone, sciadopitysin (1), two flavone O-glycosides, quercetin 3-O-${\beta}$-D-glucuronide 6"-ethyl ester (2), apigenin 7-neohesperidoside (3) in comparison with literatures data. Compounds 1-3 showed stronger antitumor activity than Taxol used as positive control. The inhibition ratio values of compounds 1-3 is 34.9, 31.6, 34.0%, respectively, and Taxol is 27.0 % compared with control group.

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