Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Various Bioactivities of Two Polyphenolic Compounds from the Brown Alga Grateoupia elliptica

  • Kim, Eun-Sook (Dept. of Chemical Technology, Hanbat National University) ;
  • Kim, Chan-Sook (Dept. of Chemical Technology, Hanbat National University) ;
  • Lee, Bong-Ho (Dept. of Chemical Technology, Hanbat National University) ;
  • Choi, Byoung-Wook (Dept. of Chemical Technology, Hanbat National University) ;
  • Ryu, Geon-Seek (Dept. of Chemical Technology, Hanbat National University)
  • Published : 2003.10.01
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Abstract

In the course of search for various bioactive compounds from marine algae, we found strong antioxidant activity of the methanolic extract of the brown alga G. elliptica. Chromatographic purification [ODS flash, gel-filtration on Sephadex LH-20, HPLC] of the BuOH layer of the methanolic extract afforded two known polyphenolic compounds, 6,6'-bieckol (1) and dieckol (2). Compound 1 showed acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities, free radical scavenging activity on DPPH (1,1-diphenyl-2-picryl-hydazyl) with IC$\_$50/ values of 91.2, 45.6 and 15.5 $\mu\textrm{g}$/$m\ell$, respectively. (omitted)

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