대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.190.2-190.2
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- 2003
Various Bioactivities of Two Polyphenolic Compounds from the Brown Alga Grateoupia elliptica
- Kim, Eun-Sook (Dept. of Chemical Technology, Hanbat National University) ;
- Kim, Chan-Sook (Dept. of Chemical Technology, Hanbat National University) ;
- Lee, Bong-Ho (Dept. of Chemical Technology, Hanbat National University) ;
- Choi, Byoung-Wook (Dept. of Chemical Technology, Hanbat National University) ;
- Ryu, Geon-Seek (Dept. of Chemical Technology, Hanbat National University)
- 발행 : 2003.10.01
초록
In the course of search for various bioactive compounds from marine algae, we found strong antioxidant activity of the methanolic extract of the brown alga G. elliptica. Chromatographic purification [ODS flash, gel-filtration on Sephadex LH-20, HPLC] of the BuOH layer of the methanolic extract afforded two known polyphenolic compounds, 6,6'-bieckol (1) and dieckol (2). Compound 1 showed acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities, free radical scavenging activity on DPPH (1,1-diphenyl-2-picryl-hydazyl) with IC
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