Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.187.3-188
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- 2003
Synthesis and Biological Evaluation of Allylamine Type Antimycotics
- Chung, Soon-Young (College of Pharmacy, Chonnam National University, Gwang Ju 500-757) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University, Gwang Ju 500-757)
- Published : 2003.10.01
Abstract
Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorphenyl, 2-fluorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 4-nitrophenyl, and 2,3-dihydro-benzo[l,4]dioxin-6-yl instead of naphthyl group with hydrogen, methyl, and ethyl in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds showed significant antifungal activity against T. mentagrophytes. (omitted)
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