Synthesis and Biological Evaluation of Allylamine Type Antimycotics

Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorphenyl, 2-fluorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 4-nitrophenyl, and 2,3-dihydro-benzo[l,4]dioxin-6-yl instead of naphthyl group with hydrogen, methyl, and ethyl in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds showed significant antifungal activity against T. mentagrophytes. (omitted)