Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.185.1-185.1
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- 2003
Cytotoxic activity of 1-phenyl-2-alkylsulfonylamido propanol derivatives
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Im, Cha-Euk
(Chung-ang University, College of Pharmacy)
;
- Chung, Mi-Ryang (Chung-ang University, College of Pharmacy) ;
- Kim, Yong-Hyun (Chung-ang University, College of Pharmacy) ;
- Yin, Chul-Bu (Chung-ang University, College of Pharmacy)
- Published : 2003.10.01
Abstract
The 20 alkylsulfonylamido propanol derivatives had been investigated for their cytotoxic activity against HT-29 colon cancer, Caki-2 renal cancer, A549 lung cancer, PC-3 prostate cancer, HL-60 leukemia cell using MTT assay. Cytotoxic activity was strongly influenced by the substituted alkyl chain length and the optimal alkyl chain length for cytotoxicity was C11. Some of alkylsulfonylamido porpanol derivatives showed stronger activity than reference compound, B13.
Keywords