Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.178.1-178.1
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- 2003
Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles
- Han, Ja-Young (College of Pharmacy, Ewha Womans University) ;
- Choi, Ik-Hwa (College of Pharmacy, Ewha Womans University) ;
- Chae, Mi-Jin (College of Pharmacy, Ewha Womans University) ;
- Jung, Ok-Jai (College of Pharmacy, Ewha Womans University) ;
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University)
- Published : 2003.10.01
Abstract
6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles. The 6-arylamino-substituted compounds exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl-or 5-methoxy-moieties of compounds did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents
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