Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Wogonin and Its Analogs

  • Jang, Jin-Hee (College of Pharmacy, Kangwon National University) ;
  • Sin, Kwan-Seog (College of Pharmacy, Kangwon National University) ;
  • Park, Hae-Il (College of Pharmacy, Kangwon National University)
  • Published : 2003.10.01
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Abstract

Our long-term research goals involve the SARs study and the synthetic procedure development of wogonin and its analogs. We investigated efficient synthetic pathways of wogonin and its bioisosteres in a large quantity to decipher the structural requirements for anti-inflammatory activities. We plan to serially delete or modify the 5,7-dihydroxyl groups of wogonin to observe the effects of the hydroxyl groups on anti-inflammatory activity. Also we modofied the 8- methoxy group on a ring since it is known to be necessary for biological activity. (omitted)

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