Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.169.2-170
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- 2003
Erythropoietin increases neuronal cell differentiation : association of transcriptional factors AP-l and NF-$\kappa$ B activation
- Lee, Sang-Min (College of Pharmacy, Chungbuk National University) ;
- Park, Hye-Ji (Korea Research Institute of Bioscience and Biotechnology) ;
- Lee, Yoot-Mo (Korea Research Institute of Bioscience and Biotechnology) ;
- Moon, Dong-Cheul (Korea Research Institute of Bioscience and Biotechnology) ;
- Kim, Kyong-Soon (Korea Research Institute of Bioscience and Biotechnology) ;
- Cho, Kyong-Ju (Korea Research Institute of Bioscience and Biotechnology) ;
-
Yoon, Do-Young
(Korea Research Institute of Bioscience and Biotechnology)
;
- Song, Suk-Gil (Korea Research Institute of Bioscience and Biotechnology) ;
- Hong, Jin-Tae (Korea Research Institute of Bioscience and Biotechnology)
- Published : 2003.10.01
Abstract
Erythropietin (EPO), a hematopoietic factor is also required for normal brain development, and its receptor is localized in brain. Therefore, it is possible that EPO could act as a neurotropic factor inducing differentiation of neurons. The present study, we therefore investigated whether EPO can increase differentiation of undifferentiated cortical neuron isolated from postneonatal (Day 1) rat brains and PC12 cell, undifferentiated dopaminagic cell line. EPO dose (1-100 U/ml) dependently increased cell differentiation and expression of differentiation marker gene (neurofilament and tyrosine hydroxylase) in both cells. (omitted)
Keywords